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Glutamatergic signaling by mesolimbic dopamine neurons in the nucleus accumbens. Conventional Theory Dopamine in motivation of reward-seeking actions Dopamine has long been known to be important for reinforcement and motivation of actions. The CeA and other amygdala nuclei contain many neurons whose signals are consistent with motivational salience: Cell type-specific loss of BDNF signaling mimics optogenetic control of cocaine reward. A conditioned stimulus decreases extracellular dopamine in the nucleus accumbens after the development of a learned taste aversion. However, recent studies indicate that this technique may be less reliable in the VTA, where DA and non-DA neurons have a wider variety of cellular properties Margolis et al.
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